· 姓名： 高永林 · 最后学历： 博士研究生 · 最后毕业院校： 中国海洋大学 · 所学专业： 食品科学与工程 · 职称/职务： 教授 · 办公电话：0535-3808298 · 电子邮件： [email protected] 个人学习工作经历 l 2007.09-2010.07, 中国海洋大学, 博士 l 2000.09-2003.07, 贵州大学, 硕士 l 1996.09-2000.07, 内蒙古农业大学, 学士 目前研究方向 l 功能性食品研究与开发 l 食品毒理学及GRAS认证评估 l 海洋生物资源开发和高值化利用 主持（或参与）的主要教学、科研项目 l 主持完成食源性生物医学材料开发与应用研究、基于人工智能的药食同源生物资源高值化利用与提质增效关键技术研究、海参超微粉和海参水煮液提取物综合开发利用等多项项目。 l 按照OECD、FDA及NMPA等法规与指导原则，与美国、韩国、加拿大及国内多家企业完成20多款功能性食品（包括海洋来源DHA、ARA、藻类提取物等）GRAS认证，目前已有7款产品通过美国FDA官方网站备案。 代表性论著 [1] Cao Y, Wu T, Li J, Zhang D, Qu C, Shen Y, Li C, Feng J, Shi G, Jiang Y, Xie Z, Liu X, Gao Y*. Identification and anti-inflammatory characterization of two triterpene glycosides from boiling waste liquid: network pharmacology, molecular docking, and in vivo evaluation. Food Res Int,2026 Feb 1:225:118046. [2] Sun Y, Wu T, Zhu Y, Zheng S, Guo Y, Lin J, Zhang H, Gao Y*. The Material Basis for the Beneficial Effects of Paidu Powder on Hyperuricemia: A Network Pharmacology and Clinical Study. J Food Biochem Volume 2025, Article ID 4962920, 13 pages //doi.org/10.1155/ jfbc/4962920. [3] Wang J, Guo S, Xie X, Ma T, Wen Q, Gao Y, Li Y, Zhang J, Li W, Zhang L. Characterization of two novel angiotensin converting enzyme-inhibitory peptides from yellow tuna peptides: Inhibitory mechanism, transport route and network pharmacology analysis. Food Res Int. Volume 209, May 2025, 116232. [4] Wu T, Han L, Zhu Y, Zeng X, Kang Y, Zheng S, Wang Z, Wang J, Gao Y* Application of decalcified bone matrix in Salmon bone for tibial defect repair in rat model. Int J Artif Organs. 2024 Oct;47(10):783-792. [5] Wang J, Qin S, Lin J, Wang Q, Li W, Gao Y*. Phycobiliproteins from microalgae: research progress in sustainable production and extraction processes. Biotech Biofuels Bioprod,2023;16(1):170. [6] Gao Y, Liu P, Wang D, Liu J, Yang L, Kang Y, Han B, Yin J, Zhu J, Wang K, Li C*. Isolation and characterization of a novel protein from Momordica charantia L. Positively regulates lipid metabolism activity in vivo and in vitro. J Funct Foods, 96 (2022) 105218. [7] Gao Y, Kang Y, Wang T, Li C, Shen S, Qu C, Gong S, Liu P, Yang L, Liu J, Han B, Li C*. Alginate microspheres-collagen hydrogel, as a novel 3D culture system, enhanced skin wound healing of hUCMSCs in rat model. Colloids Surf B Biointerfaces,2022;219:112799. [8] Li D, Wang T, Zhao J, Wu J, Zhang S, He C, Zhu M, El-Newehy, El-Hamshary M, Morsi Y, Gao Y*, Mo X*. Prodrug inspired bi-layered electrospun membrane with properties of enhanced tissue integration for guided tissue regeneration. J Biomed Mater Res B Appl Biomater. 2022;110(9):2050-2062. [9] Yang L, Chen K, Liu P, Kang Y, Shen S, Qu C, Gong S, Liu Y, Gao Y*. Preparation of Nile tilapia skin collagen powder by low-temperature and comprehensive evaluation of hemostasis and wound healing. Int J Artif Organs. 2023;46(2):99-112. [10] Gao Y, Chen X, Li C, Wang H, Tian J*, Fu F*.Toxicological evaluation of, red rice yeast extract, Xuezhikang: Acute, 26-week chronic and genotoxicity studies. Regul Toxicol Pharmacol. 2020;9:104654. [11] Li C, Wang Z, Li G, Wang Z, Yang J, Li Y, Wang H, Jin H, Qiao J, Wang H, Tian J, Lee W, Gao Y*. Acute and repeated dose 26-week oral toxicity study of 20(S)- ginsenoside Rg3 in Kunming mice and Sprague-Dawley rats. J Ginseng Res. 2020;44(2):222-228. [12] Gao Y, Wang G, Wang T, Li G, Lin J, Sun L, Wu X, Sun X, Wang H, Li C, Tian J, Zhu J, Wang K, Cho S.A 26-week 20(S)-ginsenoside Rg3 oral toxicity study in Beagle dogs. Regul Toxicol Pharmacol. 2020;110:104522. [13] Li C, Wang Z, Wang T, Wang G, Li G, Sun C, Lin J, Sun L, Sun X, Cho S, Wang H, Gao Y*, Tian J.Repeated-dose 26-week oral toxicity study of ginsenoside compound K in Beagle dogs. J Ethnopharmacol. 2020;248:112323. [14] Gao Y, Wang T, Wang G, Li G, Sun C, Jiang Z, Yang J, Li Y, You Y, Wu X, Sun L, Wang H, Li C, Tian J, Zhu J, Wang K, Cho S. Preclinical safety of ginsenoside compound K: Acute, and 26-week oral toxicity studies in mice and rats. Food Chem Toxicol. 2019;131:110578. [15] Guo W, Gao Y#, Jiang W, Li C, Lin F, Zhu H, Wang H, Ye L, Qi J, Cen X, Tian J . Toxicity effects of a novel potent triple reuptake inhibitor, LPM570065, on the fertility and early embryonic development in Sprague-Dawley rats. Regul Toxicol Pharmacol. 2018;100:45-51. [16] Gurung R, Kim D, Kim L, Lee A, Wang Z, Gao Y*. Toxicological evaluation of 6'-sialyllactose (6'-SL) sodium salt. Regul Toxicol Pharmacol. 2018;95:182-189. [17] Gao Y, Wang Y, Wang K, Zhu J, Li G, Tian J, Li C, Wang Z, Li J, Lee A, Guo C. Acute and a 28-day repeated-dose toxicity study of total flavonoids from Clinopodium chinense (Benth.) O. Ktze in mice and rats. Regul Toxicol Pharmacol. 2017;91:117-123. [18] Gao Y, Li C, Wang Y, Liu Y, Li G, Fan X, Li Y, Tian J, Lee AW. Nonclinical safety of astilbin: A 4-week oral toxicity study in rats with genotoxicity, chromosomal aberration, and mammalian micronucleus tests. Food Chem Toxicol.2017;107(Pt A):1-9. [19] Li C, Han R, Kang L, Wang J, Gao Y*, Li Y, He J,Tian J. Pirfenidone controls the feedback loop of the AT1R/p38 MAPK/ renin-angiotensin system axis by regulating liver X receptor-α in myocardial infarction-induced cardiac fibrosis. Sci Rep. 2017, 40523. [20] Gao Y, Li C, Xiao L, Jiang Z, Li Y, Susan C, Lee.W. Repeated sub-chronic oral toxicity study of xylooligosaccharides (XOS) in dogs. Regul Toxicol Pharmacol. 2017;86:379-385. [21] Li C,Gao Y*,WangY, Li G, Fan X, Li Y, Guo C, Tao J. Genotoxicity testing of sodium formononetin-3'-sulphonate (Sul-F) by assessing bacterial reverse mutation, chromosomal aberrations and micronucleus tests. Regul Toxicol Pharmacol. 2017;86:374-378. [22] Li C, Li G, Sun C, Wang X, Gao Y*. A 90-day subchronic toxicity study with Sodium formononetin-3'-sulphonate (Sul-F) delivered to dogs via intravenous administration. Regul Toxicol Pharmacol. 2016;77:87-92. [23] Gao Y, Kang L, Li C, Wang X, Sun C, Li Q, Liu R, Wang J. Resveratrol ameliorates diabetes-induced cardiac dysfunction through AT1R-ERK/p38 MAPK signaling pathway. Cardiovasc Toxicol. 2016;16(2):130-7. [24] Li G, Yang M, Hao X, Li C, Gao Y*, Tao J. Acute toxicity of sodium formononetin-3'-sulphonate (Sul-F) in Sprague- Dawley rats and Beagle dogs. Regul Toxicol Pharmacol. 2015;73(2):629-33. 学术兼职 首届驻烟高校（院所）高层次人才产学研合作“科创人才顾问”。 指导研究生情况 已毕业18名，在读4名。 |